Why is essay writing important
Can You Write About The Same Topic For More Than One Uc Essay
Thursday, August 27, 2020
Exercise Assignment Example | Topics and Well Written Essays - 500 words - 2
Exercise - Assignment Example Fillmore et als principle works are intelligible by utilization of models. For example, Fred and Andy are twin siblings and are recouping in medical clinic. For the situation, a medical caretaker goes into the room and discovers them in a similar sitting position and their wellbeing conditions are the equivalent regarding eye appraisal. On the off chance that the medical attendant reports that: presently Andy can sit well. In a similar configuration, the medical attendant reports that Fred can sit well at this point. The two same reports introduced by a similar medical caretaker are probably going to be fathomed in varying terms by others. The comprehension relies upon the relativity of the comments with serious respects to the foundation scenes. Fillmore et als generally involved the utilization of term outline concerning an admiration that involves a well-spoken and rational individuatable referent observation, experience, activity, memory, and article. Fillmore is mostly dug in on the casing semantics that is profoundly supporting with start of a concise history (Corrigan, 2009). The utilization of the edge semantics is regularly thought to be an immensely casual methodology concerning the emblematic implications yet additionally have certain methodologies that identify with outline semantics (Pawlak and Bielak, 2011). The fundamental distinction between radical development and other development language structure draws near. Radical development language structure alludes to the hypothesis that involves a syntactic that is profoundly agent that is exceptionally perfect with significant outcomes that verge on the realities of sentence structure. The pith of the extreme Construction Grammar profoundly digs on the proposed or exceptionally moderate model that involves sentence structure gathered from a widespread point of view. Radical Construction Grammar gets massively from its s name. It exceptionally demonstrates a combination of development punctuation while development language structure alludes generally to a group of speculations that has syntactic
Saturday, August 22, 2020
Essay --
John Hodges Ms. Roney World Literature 4 December 2013 Exciting modern lifestyle Essay Truth and joy share a relationship of not knowing reality, which just makes individuals more joyful. The individuals of the new world lost their opportunities yet consequently get numerous joys. This in this way adds to the fear of knowing reality. They donââ¬â¢t need to know reality since they are prepared not to and it appears they donââ¬â¢t need to know reality, either. To maintain a strategic distance from ever knowing reality they use soma. By taking somas, they maintain a strategic distance from truth at whatever point they are startled by it. It thusly disguises their distresses and rather fills them with counterfeit mind flights. In the story there are two sorts of facts. One sort of truth is identified with human connections and feelings. Feelings and connections give individuals extraordinary satisfaction, yet they likewise can cause a lot of torment. Because of these torments, nobody structures associations with the other gender. Alongside this they think of it as anomalous to feel connection to somebody. There are no couples or families and the possibility of modesty is firmly prohibited. The oth...
Friday, August 21, 2020
Cheap Term Paper Help Services
Cheap Term Paper Help ServicesIf you want to make sure that your term paper is easy and appealing, then you should hire a cheap term paper help service. There are many services which are ready to offer assistance to you, but a search for cheap term paper help will only lead you to the website of a company, which is actually producing cheap term papers and not to the same people who do it for a living.Term paper help companies generally help you by analysing the content of your term paper and writing accordingly. A good term paper will always have a well-written conclusion.While writing a term paper, it is quite easy to become confused and this is why we all need professional help. We may come across several projects and we would need to work as per the schedule. Sometimes, we can overlook some important information about the topic or we can be critical of some point and find it difficult to finish our paper.In order to do away with such problems, the term paper help companies take a look at the entire content of the paper. They also talk to the author about their opinion and they also make suggestions regarding any points of criticism and leave a comment on what they thought.The term paper help services are experts in highlighting the point and the writer must always keep a check on the tone of the paper. He must consider these services and the market price and most importantly he must ensure that he has not put any particular point in his paper.It is not possible to keep an eye on the papers in question and then to highlight the points as per the demands of the market. He needs to be confident that what he writes will be accepted by the readers. It is not an easy task and if the writer falters in this aspect, it will lead to failure.The most important part of a cheap term paper is the introduction and this is where the cheap term paper help takes a very important role. They analyse the material in order to highlight what is more important and they suggest ways in which the writer can improve his article. There is nothing wrong in using cheap term paper help services in order to bring out your best efforts in writing your term paper.All you need to do is to get in touch with the company, which is providing the services and get them to write your paper for you. The work is not only easy but also it is very fast and if you can achieve all this within the time limit, then you can be sure that your term paper will be accepted by the readers.
Monday, May 25, 2020
John Stuart Mill on Individual Liberty Essay - 2353 Words
John Stuart Mill on Individual Liberty Definition of Individual liberty In his work On Liberty, Mill placed much emphasis on individual liberty and its vital role in political society. To Mill, this phrase may be defined as the liberty of the individual to be the final judge over his actions; to decide what is right and wrong and to act upon that standard. On a secondary level, it also implies ones freedom to pursue ones own individuality. Mill believed in a society in which each individual leads his own distinctive life according to his own unique talents; unfettered by regulations upon thought, opinion, actions etc. However, Mill asserts an important caveat; that which he calls `the very simple principle. He writes, `Thatâ⬠¦show more contentâ⬠¦Value of Individual Liberty Indeed, Mill asserted that the cultivation of ones individuality should be the goal of human existence. He wrote On Liberty as an argument against repressive laws which inhibit voluntary association and suppress original ideas and ways of thinking, in a bid to protect the freedom of the individual from stifling social conventions, oppressive legal controls and censorship. What is the value of individual liberty that calls for it to be defended so fervently by Mill? Individual Liberty and Truth Firstly, Mill believes that individual liberty is instrumental in the attainment of truth. No one can claim an infallibility of knowledge or a definite truth. Falsehoods are often sprinkled with specks of truth; and truth may exists as half-truths held by different people, and it is only through controversy that the truth in the parts can be unified into a larger canvas of the ultimate truth. If ones actions were to be censored completely, society would lose those specks of truth amongst the falsehoods, which would be disadvantageous to society. Furthermore, truth is very often not derived from the masses, but from the ideas of a select few. If these people are silenced by repressive laws or mass opinion, society will be deprived of a chance to find outShow MoreRelatedJohn Stuart Mills Work881 Words à |à 4 PagesJohn Stuart Millââ¬â¢s work provides a valuable insight to the issue of medicine that harm people in the classical utilitarian. Many people consider that prescription for medical marijuana as a moral sin or something that should be given to help the patients to improve his/her bad condition. As a majority of people and federal consider prescription for medical marijuana is immoral and it is restricted in many states including Texas. In the section on liberty, John StuartRead More`` On Liberty `` By John Stuart Mill1458 Words à |à 6 PagesJohn Stuart Mill was an English philosopher and a progressive in British politics during the 17th century. He lived during a time of political transformation in England caused by the Industrial Revolution. The Industrial Revolution brought social mobility to the middle and lower class, along with more political participation. With this newfound freedom, the people of England felt their liberties were being diminished because they had the ability to accomplish all the more but in some cases, couldRead MoreJohn Locke And John Stuart Mill s On Liberty Essay1748 Words à |à 7 Pagesphilosophers over time have developed their own conceptions of liberty and the relationship of individuals to not only society, but also the state. Political philosophers such as, Aristotle and Plato have more of an ancient conception of liberty and the role the individual plays in society and to the state. Whereas, Thomas Hobbes, John Locke, and John Stuart Mill have developed a more modernized conception of liberty and the role of the individual to the state and society. Platoââ¬â¢s work the Republic, andRead MoreJohn Locke And John Stuart Mill s On Liberty Essay1200 Words à |à 5 PagesPhilosophers over time have developed their own conceptions of liberty and the relationship of individuals to not only society, but also the state. Political Philosophers such as, Aristotle and Plato have more of an ancient conception of liberty and the role the individual plays in society and to the state. Whereas, Thomas Hobbes, John Locke, and John Stuart Mill have developed a more modernized conception of liberty and the role of the individual to the state and society. Platoââ¬â¢s work the Republic, andRead MoreIndividualism And Liberty By John Stuart Mill1196 Words à |à 5 Pages In the essay, Liberty, written by John Stuart Mill, Mill states that individualism is the theory that ââ¬Å"[o]ver himself, over his own body and mind, the individual is sovereignâ⬠(7). Before coming to this conclusion, Mill first explains that individualism and liberty were defined in ways far different from definitions now and that true individualism did not exist until later in history. It takes him several paragraphs and even chapters to finally suggest that a man, by himself, is free to do whatRead MoreKarl Marx And John Stuart Mill Essay1576 Words à |à 7 PagesKarl Marx and John Stuart Mill were both philosophers who lived in the 1800s. Beginning with Karl Marx, he was a German philosopher, journalist, and revolutionary socialist. In his adult years, Marx was not recognized as a citizen of any country even though he was born in Germany and he spent most of his years in London, England. There, he continued to evolve his philosophy and social thought in participation o r collaboration with a German thinker called Friedrich Engels. They worked together andRead MoreAnalysis Of The Text On Liberty By John Stuart Mill1642 Words à |à 7 PagesAccording the text ââ¬ËOn Libertyââ¬â¢ by John Stuart Mill, his position with respect to free speech is that even one person had a specific opinion, mankind is not given grounds to silence him. Millââ¬â¢s argument regarding free speech is valid because he protects the liberty of the individual over the popular opinion of society. I agree with Millââ¬â¢s point of view because I also believe that everyone should have the voice to express what they wish, excluding when it causes harm to others. Mill begins the text byRead MoreThe Impact Of Media On American Society1640 Words à |à 7 Pages John Stuart Mill in a post 9/11 Western Society Adam Kershek History 1002-106: Growth of Western Civilization Since 1715 November 2, 2017 It is no mystery that 9/11 brought upon change in American society. The lasting effects of this unforgiving event, such as, the ongoing wars, the severity of immigration and deportation laws, and the increase in racial profiling, continues to disrupt American society. This brings up an important question: Why are these still lasting issues inRead MoreMarx, Mill And Freud s Critique Of Political Economy And The Communist Manifesto Essay1133 Words à |à 5 Pagesmerely implicit) notions of freedom and unfreedom we find in the texts we have read by Marx, Mill and Freud. Use the esoteric traditions we have examined thus far (from the Book of Job to Plato) as a comparative yardstick, or point of reference, but without letting them take over the foreground in your paper -- the latter should be reserved for these three figures. Karl Marx, Sigmund Freud, and John Stuart Mill are three authors who tackle the topic of freedom in unique ways, but their messages areRead MoreAccording to Mills, government should not be attempting to control individual freedoms, but should1100 Words à |à 5 Pages According to Mills, government should not be attempting to control individual freedoms, but should be helping individuals develop in society. A society is only as great as the people who are in it. How a person develops should be up to them, but a government should support that development. Ensuring a free flow of factual information and opportunities for open discussion are ways a government can help. Again, he uses history as his support. He says that the history of mankind is a history of intellectual
Friday, May 15, 2020
The Dramatic Effectiveness of Three Soliloquies in Romeo...
The Dramatic Effectiveness of Three Soliloquies in Romeo and Juliet Romeo and Juliet was written in the early 19th century. The play was written at the peak of William Shakespeares work and is considered as one of his most poetic plays. The choice of language is greatly varied and can be very emotional. It creates a great atmosphere and a superb play. During the play, Shakespeare uses many long and emotional speeches. These are called soliloquies. These soliloquies communicate with the audience sometimes creating dramatic irony. The long soliloquies also help to further the plot and they also include emotions of the characters and information about them. The soliloquies also differ fromâ⬠¦show more contentâ⬠¦He compares the natural flowers to a feeding baby, then again explaining that all good can turn to bad. The flowers can be a vital medicine, or can be a poison that could kill that same person. This is emphasising on the fact that everything should be treated with respect. In this soliloquy, there is a great deal of emotion towards the flowers. Friar Lawrence treasures them as they bring him lots of good. Romeo is on his way to Friar Lawrence whilst Friar Lawrence is saying his soliloquy. Romeo wants to ask Friar Lawrence to marry Romeo to Juliet. We soon find out that Friar Lawrence does marry them as he thinks that it will stop the family from feuding. The audience are happy that Romeo and Juliet are going to get married, but they are also scared in case they get caught. The next soliloquy I am going to study is taken form Act 4, Scene 3. This scene takes place in Juliets bedroom. She has told her father that she is willing to marry Paris, but through dramatic irony we know that she intends to fake her death and to be with Romeo. A great del has happened before and leading up to Juliets soliloquy. For example, Romeo has been banished from Verona and Tybalt, Juliets cousin is dead. Friar Lawrence has planned to write a letter to Romeo explaining what is going to happen and what Romeo has to do. Again though dramatic irony we know that thisShow MoreRelatedGender Roles and Attitudes toward Love in Shakespeares Hamlet5989 Words à |à 24 PagesRomeo and Juliet is a heart-breaking tragedy written early in the career of playwright William Shakespeare telling us the story of two teenage ââ¬Ëstar-crossââ¬â¢d loversââ¬â¢ whose unfortunate deaths ultimately unite the dispute between their two families. Despite the perils involved, they fall in lov e and marry with the help of two characters, Friar Lawrence and the Nurse. Throughout the play, Shakespeare portrays a range of different kinds of love through the central female characters. Maternal love is offeredRead MoreAmerican Literature11652 Words à |à 47 Pagesmanuscript is now in the British Library, but has been made accessible to all by The Electronic Beowulf Project. It was once owned by Sir Robert Bruce Cotton, an antiquary or collector of Anglo-Saxon Charters and manuscripts, whose library was among three foundation collections brought together by the creation of the British Museum in 1753. Read the story of Beowulf Important Terms Primary Epic: an epic is a poem that records and celebrates the heroic achievements of an individual or individuals
Wednesday, May 6, 2020
Public Land Of Public Lands - 959 Words
Public lands that allow us to easily access natural amenities have received more attention recently in the sense that they provide quality of life for residents and recreational opportunities for tourists. These characteristics of public lands provide economic benefits for communities adjacent to public lands. These communities refer to gateway communities, which have economic ties to public lands and provide necessary services for visitors to public lands (Kurtz, 2010; U.S. House of Representatives, 2005). Examples include towns abut to national and state forests, monuments, parks, wildlife refuge, lakeshores, scenic riverway, and recreation area (Kurtz, 2010). These communities generally have a smaller population base and yet are ââ¬Å"hotspotsâ⬠that experience rapid population and economic growth (Hester, 2013). In addition, they have characteristically relied on relatively few or even a single source to drive the local economy (Kurtz, 2003). Traditionally, most gateway communities have economically depended on resource extraction industries. However, advocates of the preservation of public lands, incited through a rise in environmental awareness and movement, urged elected officials to establish strong resources protection laws (Foresta, 1984; Wirth, 1980). From the 1960s through 1980, congress responded and passed a variety of acts such as the Endangered Species Act of 1973 (Public Law 91-135; 16 U.S.C 1531-1544, 87 Stat. 884), Federal Land Policy and Management Act of 1976Show MoreRelatedProblem Statement Versus Needs Assesment1384 Words à |à 6 Pageswill be stated either as a reduction of what is currently a problem or an enhancement of a need to be added to a current situation. For example, letââ¬â¢s look at a fictitious rural community facing a particular environmental situation. The federal public land manager in charge of a watershed surrounding the small, rural community of Cottonwood Creek brings a partnership of local stakeholders together worried about the namesake stream that flowed through their town of 4,000 people. The meeting includesRead MoreThe Loss Of Public Farming Land741 Words à |à 3 PagesIn addition to the loss of public farming land, the opportunity arose for far wealthier citizens to expand the Roman latifundia (large plantation estates) as prices declined. This expansion also increased the already existing practice of slavery and drove smaller subsistence farmers off of the land, both by legal and illegal means. ââ¬Å"The rich began to offer larger rents and drove out the poor. Then the poor, who had been ejected from the land, no longer showed themselves eager for military serviceRead MoreEssay about Public Grazing Lands1857 W ords à |à 8 Pagesgrazing of public lands has become a very controversial issue over the last couple of decades. This is due to the fact that there are some people who believe that grazing the land is beneficial to the wildlife and the different plant species there. Then there are other people who have the belief that the grazing of livestock on public lands is detrimental to wildlife and plant health. Therefore, they believe that it is actually doing more harm than good. What are Public Grazing Lands? Public landsRead MoreAdvantages of Grazing Cattle on Public Lands782 Words à |à 3 Pages Grazing cattle on public lands can have many advantages. Monetary gain is a large reason why lands are utilized (Council for Agricultural Science, Livestock Grazing on Federal Land). However grazing may be used as a tool for managing rangelands. Grazing could have possibly been the first form of rangeland management other than fire (Frost, Prescription Grazing). With this method, weeds and other undesirable vegetation were targeted to reduce numbers. However, if prescribed incorrectly it couldRead MoreProject Report731 Words à |à 3 PagesPurifying Public Plots I will volunteer at the National Public Lands Day event at Big Morongo Canyon Preserve. This event involves repairing fences, trails, and signs at the preserve. The preserves volunteer coordinator, Leslie Burkhardt, will coordinate the event. The reason why this project is important is that it gives me a chance to work with land that I have access to, but have not done any work to deserve access. First, I need to take to complete this project, is to get all of the waiverRead MorePublic Land Policy, And The Wilderness Act Of 1964845 Words à |à 4 Pages1. Introduction For the past decades, public land policy debates have intensified among scholars, planners, and policy makers. The root of the debates is a question of which types of public lands management can provide better economic benefits to adjacent regions that are referred to gateway communities. For a long time, resource extractive industries ââ¬â such as mineral, oil, coal, and timber development sectors - have been a primary growth engine for the economic growth in those communities. HoweverRead MoreThe Land Is Public Property In Ethiopia Case Analysis741 Words à |à 3 PagesThe land is public property in Ethiopia [Gebreselassie 2006]; both rural and urban lands are made available to the investors at a competitive price on a Lease-Hold basis. The Lease or Rental value of land and fixed assets may transfer to the third party, but not the land. Incidentally, about the capital requirement, to assist investors to decide to invest on their own or jointly with the domestic investors the m inimum capital required for a single project has been apprehended. Under the InvestmentRead MoreThe Control of Public Land and the Consequences of Global Climate811 Words à |à 3 Pagesworldââ¬â¢s largest known concentrations of oil shale and tar sands. More than 70 percent of oil shale in America can be found within federal lands in Wyoming, Colorado, and Utah. There are 50 confirmed tar sands deposits found in eastern Utah, with more suspected to be in the area. The Bureau of Land Management has already approved the lease of over 800,000 acres of land for tar sand and shale oil development across what is known as the Green River Formation. The combined oil reserve is estimated to beRead MoreA Research Study On The School Fire Occurred On Public Land1455 Words à |à 6 Pagesdifference in the tree seedling densities as compared to unlogged sites? My hypothesis for this question is that there will be a greater density of tree species in the salvage logged site than the unl ogged site. Methods The School Fire occurred on public land in Washingtonââ¬â¢s Umatilla National Forest in August, 2005. It burned approximately 21,000 ha of grassland and mixed conifer forest (Figure 1). Pre-disturbance stand structure of the mixed conifer forest in the area was dominated by ponderosa pineRead MoreAboriginal Reservation Land Be Compulsorily Acquired For The Purpose Of Public Works1215 Words à |à 5 PagesMaori reservation land be compulsorily acquired for the purpose of public works by the Minister of Land Information? No, according to legislation to primary legislation Te Ture Whenua Maori Act 1993 and the Public Works Act 1981 and a recent decision from the New Zealand Environment Court. In Grace .v. Minister for Land Information (2014), a New Zealand Environment Court (NZEnvC) case, the primary legal considerations regarding compulsory public works acquisitions of Maori land were brought to the
Tuesday, May 5, 2020
Aggregates Modulate Neuronal Survival â⬠Free Samples to Students
Question: Discuss about the Aggregates Modulate Neuronal Survival. Answer: Introduction: The Chosen paper is about neurodegenerative disease, which is caused due to Degeneration or regular date of neuron a cells. Cerium oxide nanoparticle (CeONPs) is believed to be one of the essential element that can be used for the treatment of neurodegenerative disorder. The current paper discusses about importance of Cerium oxide nanoparticle that are used for the treatment of neurological disorder including Alzheimer's and Parkinson's disease. Multiple sclerosis, ischemic stroke and amyotrophic lateral sclerosis are few of the other common forms of Neurological disorders that are discussed in the given paper management. This is one of the main findings of the papers is related to the therapeutic use of the Cerium oxide nanoparticles that seems to have Antioxidant activity within the neurogenetics cells. One of the major cause of Alzheimer's disease is degeneration of brain-derived neurotrophic factor protein (BDNF), which is considered to be the main biomolecules for memory formation inside brain (Castrn and Kojima 2017). The reduced amount of bdnf in brain is directly linked with degradation of neuron cells. The experiment conducted by Cimini et al. (2012) have discussed about the Neuroblastoma cells, which are used in the treatment of Alpha Beta cell line. The CeONPs are used in the purpose of Signal transduction pathway in regeneration of neural cells that are used in memory storage. Alpha beta factor of CeONPs help to induce mitochondrial fragmentation that are used to revive the cells in memory generation management. The use of CeONPs has been effective in the treatment of Parkinson's disease, which is mainly caused due to exposure of neuron cells to manganese. The antioxidant nature of CeONPs used in the measurement of cell metabolism, which is believed to have a significant impact on the regeneration of neural cells. The paper has also discussed about application of CeONPs in treatment of other neurodegenerative disorder including multiple cirrhosis. In vitro experiment has proved that CeONPs can be stabilized with the use of citrate and polyethylene glycol. The future relevant research work needs to accurately focus of on the usages of CeONPs with specific focus on its ROS-scavenging property. It is also important to design drugs for better encapsulating potential of CeONPs. This will help in the purpose of Oxidative stress reduction and thereby help in the purpose of fibrillation and kintices of CNS protein. All the family of protein under CNS need to be given special focus in order to improve the treatment quality of both Alzheimer's and Parkinson's disease. Contribution of the paper in the study of neurodegenerative disease The main focus point about the selected research paper is the discussion made related to CeONPs and its oxidative property that are used in the treatment of neurodegenerative diseases. Previous research experiment by Dillon et al. (2011), have describe the importance of Cerium Oxide Nanoparticles to protect against the MPTP induced Dopaminergic Neurodegeneration. The mouse model has been used for the given purpose the understand the impact of the same on Parkinson's disease. The free radicals of CeONPs that act as the free scavenger has been studied to understand its impact in the purpose of regeneration. This previous research work has helped the current paper to review the same in context of future potential of CeONPs as nanoparticles that are used for the purpose of Neurodegenerative treatment. The research work by DeCoteau et al. (2016), have describe the function of CeONPs that are used to neutralize reactive Oxygen and nitrogen species, which is believed to induce oxidative stress. This is responsible for causing amyotrophic lateral sclerosis that is one of the major Neurodegenerative diseases. The current paper has therefore been able to review the antioxidant property of cerium oxide nanoparticle. Potential advancement in the neural and clinical settings The potential advancement that is being highlighted in the paper is the advancement in the treatment of the neurodegerative disease. According to Naz et al. (2017), CeONP can be effectively used in the treatment of Alzheimers disease. The treatment of CeONP is mainly based on the anti-xidant activity of CeONP. This is stated as the potential advancement because, according to Padurariu et al. (2013), one of the leading biological mechanism behind the development of the Alzheimers disease is the increase in the level of the oxidative stress as highlighted by the stress theory of agving. Thus this antoxidnat therapy mainly targets the reactive oxygen species which is generated from the biochemical mechains of ageining and thereby helping in the treatement of Alzheimers disease. Earlier the main treatment of the Alzheimers diease mainly involved around the use of transcranial brain stimulation but according to Nardone et al. (2012) transcranial brain stimulation induce short-duration ben eficial effects. Thus were not optimally capbale towards establishing significant evidence for therapeutic efficacy. According to Douaud et al. (2013), Vitaim B is also use towards the treatment of the alzheimers diease but this therapy is mostly directed towards the gray matter atrophy and thus in majority of times is regarded to be non-specific. The results highlighted in the study of Naz et al. (2017) showed that the CeONP is effective in the disruption of the neurofibrirally tangles which are deposited in the hippocampus of the brain. Thus the target of CeONP is specific and thereby making it a potential therapy plan of in the domain of the dieases related to neuroscience. Accoridng to Naz et al. (2017), antioxidants property of CeONP can also be utilised for the treatment of the another neurodegerative disease, Parkinson, multiple sclerosis, and laterial sceloris. This findings are extremely significant because, this kind of neurdegerative disease is fatal. It mainly effect tha t dopaminergic cells of the brain which increases the level of stress among the neuronal cells via creating disruption in the autophagic catabolism, endiplasmic reticulum stress mitochondrial dysnfunction and loss of calcium homeostatsis. All these biochemical mechanism are extremely significant of miantainng equilibirum in the body and any disruption in this mechanism leads to fatal outcomes (Michel, Hirsch and Hunot 2016). Thus providing a substitute treatment plan in order to treat fatal neurodegerative disease is indeed a significant approach in neurosicnece. Moreover, CeONP provides oxidative stress relief which helps in the possible clearance of the stress factor over the endoplasmic reticulum and over the mitochondria and thereby helping to reduce the chrinicty of the disease (Michel, Hirsch and Hunot 2016). Naz et al. (2017) have further recommended that the presence of amalgamated valence states along with extraordinary antioxidant properties conatined in the CeONPs make th em one of the prospective therapeutic target for the treatment of some of the fatal yet common neurodegerative diseases. The unique redox property possessed by cerium oxide present them as one of the potent antioxidants in comparison to other ROS modulators. Moreover, CeONP have long half life further making them potent for the targeted delivery into the body without loss in the efficiay of the particile. Legal and ethical issues related to the paper There are no significant legal and ethical isssues that can be highlighted in this paper. This because. The paper is mostly based on the summary of the recent findings in the domain of CeONP treatment in variour neurological dieases like Alzheimers diease, Parkinsons diease, multiple sclerosis and lateral scelrosis. However, according to the Paraho et al. (2014), while conducting the systematic review, proper citation of the each are very paper along with thorugh documentation is mandatory in order to avoid the ethical and legal threat of plagiarism. The study conducted by Naz et al. (2017) have succinately referenced all the required citation along with the detailed elaboration in the reference list. However, there are no significant indication of whether the paper selected for the systetamic review is based on the human trials or animal trial. Further elaboration of the trail nature of the paper selected for the review is mandatory in order to make the paper more ethically and lega lly authentic (Parahoo 2014). Reference Castrn, E. and Kojima, M., 2017. Brain-derived neurotrophic factor in mood disorders and antidepressant treatments. Neurobiology of disease, 97, pp.119-126. Cimini, A., DAngelo, B., Das, S., Gentile, R., Benedetti, E., Singh, V., Monaco, A.M., Santucci, S. and Seal, S., 2012. Antibody-conjugated PEGylated cerium oxide nanoparticles for specific targeting of A aggregates modulate neuronal survival pathways. Acta biomaterialia, 8(6), pp.2056-2067. DeCoteau, W., Heckman, K.L., Estevez, A.Y., Reed, K.J., Costanzo, W., Sandford, D., Studlack, P., Clauss, J., Nichols, E., Lipps, J. and Parker, M., 2016. Cerium oxide nanoparticles with antioxidant properties ameliorate strength and prolong life in mouse model of amyotrophic lateral sclerosis. Nanomedicine: Nanotechnology, Biology and Medicine, 12(8), pp.2311-2320. Dillon, C.D., Billings, M., Hockey, K.S., DeLaGarza, L. and Rzigalinski, B.A., 2011. Cerium oxide nanoparticles protect against MPTP-induced dopaminergic neurodegeneration in a mouse model for Parkinsons disease. Nanotechnology, 3, pp.451-454. Douaud, G., Refsum, H., de Jager, C.A., Jacoby, R., Nichols, T.E., Smith, S.M. and Smith, A.D., 2013. Preventing Alzheimers disease-related gray matter atrophy by B-vitamin treatment.Proceedings of the National Academy of Sciences,110(23), pp.9523-9528. Michel, P.P., Hirsch, E.C. and Hunot, S., 2016. Understanding dopaminergic cell death pathways in Parkinson disease.Neuron,90(4), pp.675-691. Nardone, R., Bergmann, J., Christova, M., Caleri, F., Tezzon, F., Ladurner, G., Trinka, E. and Golaszewski, S., 2012. Effect of transcranial brain stimulation for the treatment of Alzheimer disease: a review.International Journal of Alzheimers Disease,2012. Naz, S., Beach, J., Heckert, B., Tummala, T., Pashchenko, O., Banerjee, T. and Santra, S., 2017. Cerium oxide nanoparticles: a radicalapproach to neurodegenerative disease treatment.Nanomedicine,12(5), pp.545-553. Padurariu, M., Ciobica, A., Lefter, R., Lacramioara Serban, I., Stefanescu, C. and Chirita, R., 2013. The oxidative stress hypothesis in Alzheimers disease.Psychiatria Danubina,25(4), pp.0-409. Parahoo, K., 2014.Nursing research: principles, process and issues. Palgrave Macmillan.
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